Supplement Reviews

We review natural GLP-1 alternative supplements the same way every time: grade the evidence, state the verdict plainly, and cite the sources — including where the research is weak or missing.

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Purisaki Berberine Patches

3.5 / 5

Purisaki is a transdermal berberine patch aimed at people who want a non-prescription, no-injection metabolic support option. Berberine itself has reasonably consistent (if limited-quality) evidence for improving blood sugar and lipids, and a small effect on weight of roughly a kilogram in trials.

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We currently review one product. We add reviews only when we can evaluate them to the same evidence standard.